幼年感染细菌内毒素与成年后多种疾病易感性的关系

Effect of neonatal endotoxin exposure on the predisposition to a variety of diseases in adulthood

生命早期的"环境因素"与成年后许多病理学易感性的改变有关。研究显示,幼年时期感染细菌内毒素与成年后炎症性、自身免疫性、代谢性、神经精神性疾病及肿瘤的发生密切相关。本文系统综述了幼年时期受细菌内毒素损害对成年后多种疾病的发生所起的"远隔后效应",讨论了幼年感染细菌内毒素是否通过影响神经内分泌系统和免疫系统的发育从而改变成年个体神经内分泌系统和免疫系统的功能以及对多种疾病的易感性,揭示了幼年时期的感染和炎症因素是规划个体神经内分泌系统和免疫系统发育的重要刺激因子。

Early life environmental factors have been associated with altered predisposition to a variety of pathologies. Researches demonstrated that early life exposure to endotoxin is associated with inflammatory, autoimmune, neuropsychiatric disease and the tumor resistance. This paper summarizes the remote effects of neonatal endotoxin challenge on the predisposition to a variety of diseases in adulthood. It also discusses whether neonatal endotoxin exposure influence the development of neuroendocrine system and immune system, and could therefore alter neuroendocrine system and immune system function, as well as the predisposition to disease, thus revealing a role for early life inflammation and infection as an important factor programming the development of neuroendocrine system and immune system.