宫颈癌疫苗的现状和前景

The present situation and the future of vaccines for cervical cancer

宫颈癌的发病率和病死率较高,宫颈癌疫苗的应用是一种控制宫颈癌发生的重要的预防手段。目前疫苗存在诸多问题,如预防性疫苗对已经感染HPV的患者或确诊为癌前病变及宫颈癌的患者则无治疗作用,且大部分疫苗都只针对该疫苗所包含的HPV特异型产生保护作用等。因此,本文就有关宫颈癌疫苗的临床前和临床研究现状综述如下,并探讨宫颈癌疫苗的临床应用前景。

Cervical cancer causes significant morbidity and mortality worldwidely. The preventive cervical cancer vaccines have been shown to play a key role to decrease the incidence and burden of disease. However, current prophylactic vaccines offer no thera- peutic benefit for persons already infected with HPV or persons with precancerous lesions or cervical cancer. Moreover, the protection offered by current vaccines is primarily against HPV types used to derive the vaccine. Herein, we describe findings from preclinical and clinical studies that employ vaccine strategies that have the potential to shape the future of vaccines against cervical cancer.