六价铬对男工血清及精浆乳酸脱氢酶C_4同工酶的影响

Effects of Chromium on LDH\|X in Serum and Seminal Plasma from Male Exposed Workers

为了调查六价铬对男性生殖功能的危害，采用“热解－乳酸基质法”测定了２３名接铬男工和２１名对照男工的血清及精浆乳酸脱氢酶Ｃ４同工酶（ＬＤＨＸ）活性。结果显示，职业性接触低水平六价铬（００１３５ｍｇ／ｍ３）可致男工血清ＬＤＨＸ活性降低，与对照组比较差异有统计学显著意义（Ｐ＜００５）。接触组精浆的乳酸脱氢酶（ＬＤＨ）总活性及ＬＤＨＸ活性均显著低于对照组（Ｐ＜００１），ＬＤＨＸ／ＬＤＨ比值也低于对照组，提示六价铬对男性生殖功能可能产生危害。

To investigate the effects of chromium on male reproductive function,the LDH\|X activity in serum and seminal plasma from 23 male workers exposed to chromium and 21 male controls was determined by means of so called\!hot digestion\|lactate matrixmethod.The results showed that the LDH\|X activity in serum of the workers exposed in low concentration was significantly lower than that of the controls( P <0\^05).The LDH and LDH\|X activities in seminal plasma in the exposed group were markedly lower than those in the control group( P <0\^01).The ratio of LDH\|X to LDH in the exposed group was also obviously lower than that in the control group.This suggested that reproductive dysfunction might probably be resulted in male exposed workers.