江西省80例汉族人MMP-1基因多态性与COPD易感性的关系被引量：4

下载PDF

导出

摘要目的探讨中国南方汉族人群基质金属蛋白酶-1(MMP-1)基因多态性在慢性阻塞性肺疾病(COPD)发病中的作用。方法选择江西省80例吸烟COPD患者(观察组)及90例吸烟非COPD者(对照组),应用PCR-限制性片段长度多态性法(PCR-RELP)检测两组MMP-1基因型。结果观察组MMP-1基因突变型(2G/2G)、杂合型(2G/1G)、野生型(1G/1G)频率分布分别为65.0%(52/80)、27.5%(22/80)和7.5%(6/80),对照组分别为54.4%(49/90)、28.9%(26/90)和16.7%(15/90)。观察组野生型MMP-1基因频率显著低于对照组(P<0.05)。结论中国南方汉族人群MMP-1基因多态性与COPD发病有关,野生型(G/G)MMP-1基因对COPD发病可能有预防作用。

作者蔡金莲王红鸾王爱平

机构地区江西省人民医院

出处《山东医药》 CAS 北大核心 2010年第23期76-77,共2页 Shandong Medical Journal

关键词肺疾病阻塞性慢性基质金属蛋白酶-1 基因多态性

分类号 R563.9 [医药卫生—呼吸系统]

引文网络
相关文献

参考文献5

1曲仪庆,黄绍光.慢性阻塞性肺疾病易感性基因研究进展[J].中国呼吸与危重监护杂志,2003,2(4):249-252. 被引量：6
2Nagase H,Woessner JF Jr.Matrix metalloproteinase[J].J Biol Chem,1999,274 (31):21491-21494.
3Lowrey GE,Henderson N,Blakey JD,et al.MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD[J].Respir Med,2008,102(6):845-851.
4Joos L,He JQ,Shepherdson MB,et al.The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function[J].Hum Mol Genet,2002,11(5):569-576.
5Mercer B,Brinckerhoff C,Armiento J.Activation of the MMP-1 promoter by cigarette smoke in human small airway epithelial cells requires ERK MAP kinase signaling:differential response of the 1G and 2G promoter sequences[J].Proc Am Thorac Soc,2006,3(6):477.

二级参考文献34

1[1]Hautamki RD,Kobayashi DK,Senior RM,et al.Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice.Science,1997;277:2002～2004
2[2]Segura-Valdez L,Pardo A,Gaxiola M,et al.Upregulation of gelatinases A and B,collagenases 1 and 2,and increased parenchymal cell death in COPD.Chest,2000;117:684～694
3[3]Minematsu N,Nakamura H,Tateno H,et al.Genetic polymorphism in matrix meta-lloproteinase-9 and pulmonary emphysema.Biochem Biophys Res Commun,2001;289:116～119
4[4]Joos L,He JQ,Shepherdson MB,et al.The role of matrix metalloproteinase po-lymorphisms in the rate of decline in lung function.Hum Mol Genet,2002;11:569～576
5[5]Ohnishi K,Takagi M,Kurokawa Y,et al.Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema.Lab Invest,1998;78:1077～1087
6[6]Hirano K,Sakamoto T,Uchida Y,et al.Tissue inhibitor of meta-lloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease.Eur Respir J,2001;18:748～752
7[7]Cantly AM,Lamb D,Gillooly M,et al.Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer.J Clin Pathol/Mol Pathol,1995;48:M210～M214
8[8]Smith CA,Harrison DJ.Association between polymorphism in gene for mic-rosomal eposide hydrolase and susceptibility to emphysema.Lancet,1997;350:630～633
9[9]Sandford AJ,Changni T,Weir TD,et al.Susceptibility genes for rapid decline of lung function in the lung health study.Am J Respir Crit Care Med,2001;163:469～473
10[10]Yosnikawa M,Hiyama K,Ishioka S,et al.Microsomal epoxide hydrolase ge-notypes and chronic obstructive pulmonary disease in Japanese.Int J Mol Med,2000;5:49～53