肌红蛋白在急性冠脉综合征的临床意义

Clinical Value of Myoglobin in Acute Coronary Syndrome

目的探讨肌红蛋白(MYO)、肌钙蛋白(cTnT)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)在急性冠脉综合征(ACS)中的作用。方法采用不同方法检测急性冠脉综合症(ACS)患者及对照组血浆中肌红蛋白(MYO)、肌钙蛋白(cTnT)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)水平。结果肌红蛋白在心肌梗死组明显高于心绞痛及健康组(P<0.01);且酸碱性明显高于cTnT、CK、CK-MB(P<0.01);血浆MYO含量在0支病变组与单支病变组、多支病变组中的差异有统计学意义(P<0.01)。结论 MYO升高在ACS的发生、发展中起重要作用,可作为ACS的又一危险因素及诊断依据。

Objective To explore the effect of myoglobin （MYO）,cardiac troponin T （cTnT）,creatine kinase （CK）,creatine kinase isoenzyme-MB （CK-MB） in patients with acute coronary syndrome （ACS）.Methods Serum levels of MYO,cTnT,CK,and CK-MB of ACS group and control group were detected by different detection methods.Results Serum level of MYO in myocardial infarction group was significantly higher than those of angina pectoris group and healthy control group （P〈0.01）,and the acidity and basicity of MYO were significantly higher than those of cTnT,CK,and CK-MB （P〈0.01）.There were statistically significant differences in the concentration of MYO among non-vessel disease group,single-vessel disease group and multi-vessel disease group （P〈0.01）.Conclusions The increased level of MYO plays an important role in the occurrence and development of acute coronary syndrome.It can be used as a risk factor and diagnostic evidence in acute coronary syndrome.