独活对痴呆大鼠脑中p38MAPK信号转导通路的影响被引量：9

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摘要目的探讨祛风除湿中药独活对Aβ脑内注射所致大鼠痴呆模型的脑保护作用。方法 30只雄性Wistar大鼠行颅内Aβ蛋白海马CA1区内注射,随机分为丹参组、独活组、西药组、假手术组和模型组,每组6只,分别给予丹参、独活、吲哚美辛及生理盐水灌胃。实验4w末处死动物,检测p38MAPK,在大鼠脑中表达情况。结果实验后各组除假手术组外,其水迷宫实验数值均有不同程度的改变,p38MAPK在不同组别大鼠脑中的表达有所不同,中药独活可抑制p38MAPK在大鼠脑中的表达(P<0.05)。结论独活可以改善痴呆模型大鼠的学习记忆能力,并可抑制p38MAPK在痴呆模型大鼠脑中的表达。

作者张杰杜文彬

机构地区辽宁中医药大学附属医院

出处《中国老年学杂志》 CAS CSCD 北大核心 2010年第11期1514-1515,共2页 Chinese Journal of Gerontology

基金辽宁省教育厅课题(20060664)

关键词阿尔茨海默病 Β淀粉样蛋白 P38MAPK通路

分类号 R542.2 [医药卫生—心血管疾病] R285.5 [医药卫生—中药学]

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