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基于功能的疾病基因预测系统设计与应用 被引量：2

Design and Application of Disease Gene Prediction System Based on Function
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摘要 针对与某种特定器官组织相关的疾病,利用新基因识别、基因功能预测以及疾病基因预测等技术,提出并实现一个基于基因功能信息的疾病候选基因预测系统。将其用于心血管疾病相关基因的大规模分析与预测,结果证明,该系统可以对疾病候选区间的已知基因进行致病可能性的鉴别,发现新基因,并判定新基因与疾病的相关程度。 Aiming at the diseases related with specific organs or tissues, this paper uses new gene identifying technology, gene function predicting technology and disease gene finding technology to propose and develop a candidate disease gene prediction system based on gene functional information. This system is applied for large-scale analysis and prediction of disease genes involved in cardiovascular, and result proves that the system can identify the known genes in the chromosomal region of interest, find new genes and evaluate the relation degrees of the new genes to the disease.
作者 袁芳 王瑞春 管明祥 周艳红
机构地区 深圳信息职业技术学院电子通信技术系 华中科技大学湖北生物信息与分子成像重点实验室
出处 《计算机工程》 CAS CSCD 北大核心 2010年第12期259-261,共3页 Computer Engineering
基金 国家自然科学基金资助项目(90608020) 深圳信息职业技术学院第二批博士创新基金资助项目(BC20090011)
关键词 疾病基因 基因本体 预测 心血管 disease gene Gene Ontology（GO） prediction cardiovascular
分类号 Q343.1 [生物学—遗传学]
  • 相关文献

参考文献9

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共引文献6

同被引文献11

  • 1Aerts S, Gene Prioritization Through Genomic Data Fusion[J]. Nature Biotechnol, 2006, 24(5): 537-544.
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  • 4Turner F S, Clutterbuck D R, Semple C A. POCUS: Mining Genomic Sequence Annotation to Predict Disease Genes[J]. Genome Biology, 2003, 4(11): 75-83.
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二级引证文献4

计算机工程
2010年 第12期

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