摘要
目的:探讨Apelin及胰岛素抵抗在儿童单纯性肥胖发病中的相关性。方法:以42例单纯性肥胖儿童为研究对象,并以40例同期非肥胖性儿童为对照,检测Apelin水平及胰岛素抵抗(HOMA2-IR)的变化。结果:单纯性肥胖患儿Apelin水平(t=2.483,P=0.015)和HOMA2-IR(t=12.368,P=0.0001)均较非肥胖患儿增高。Apelin水平与HOMA2-IR和BMI均呈呈正相关,相关系数r分别为0.768(t=6.253,P=0.0001)和0.754(t=5.641,P=0.004)。Apelin与HOMA2-IR也与儿童单纯性肥胖发病独立相关,OR值分别为1.416(P=0.017)和1.394(P=0.028)。结论:单纯性肥胖儿童血Apelin水平增高与患儿胰岛素抵抗有关。
Objective:To investigate the relationship between Apelin insulin resistance and simple obesity in children.Methods:42 children with simple obesity were enrolled in the study,40 non-obese children as control.All of them were detected for Apelin and insulin resistance(HOMA2-IR).Results:The Apelin in children with simple obesity were higher than those in non-obese children(t=2.483,P = 0.015),and HOMA2-IR hoved the same trends(t = 12.368,P = 0.000 1).Apelin and HOMA2-IR also have positive correlation with BMI,the correlation coefficient r was 0.768(t = 6.253,P = 0.000 1)and 0.754(t = 5.641,P = 0.004),each.Apelin and HOMA2-IR were also independent factors associated with children simple obesity,OR was 1.416(P=0.017)and 1.394(P=0.028),respectively.Conclusions:Increased Apelin level in children with simple obesity may associated with insulin resistance.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第5期771-773,共3页
Journal of Chongqing Medical University