单纯性肥胖儿童血清Apelin水平变化及其与胰岛素抵抗的关系研究

The relationship between apelin serum levels and insulin resistance in children with simple obesity

目的:探讨Apelin及胰岛素抵抗在儿童单纯性肥胖发病中的相关性。方法:以42例单纯性肥胖儿童为研究对象,并以40例同期非肥胖性儿童为对照,检测Apelin水平及胰岛素抵抗(HOMA2-IR)的变化。结果:单纯性肥胖患儿Apelin水平(t=2.483,P=0.015)和HOMA2-IR(t=12.368,P=0.0001)均较非肥胖患儿增高。Apelin水平与HOMA2-IR和BMI均呈呈正相关,相关系数r分别为0.768(t=6.253,P=0.0001)和0.754(t=5.641,P=0.004)。Apelin与HOMA2-IR也与儿童单纯性肥胖发病独立相关,OR值分别为1.416(P=0.017)和1.394(P=0.028)。结论:单纯性肥胖儿童血Apelin水平增高与患儿胰岛素抵抗有关。

Objective：To investigate the relationship between Apelin insulin resistance and simple obesity in children.Methods：42 children with simple obesity were enrolled in the study,40 non-obese children as control.All of them were detected for Apelin and insulin resistance（HOMA2-IR）.Results：The Apelin in children with simple obesity were higher than those in non-obese children（t=2.483,P = 0.015）,and HOMA2-IR hoved the same trends（t = 12.368,P = 0.000 1）.Apelin and HOMA2-IR also have positive correlation with BMI,the correlation coefficient r was 0.768（t = 6.253,P = 0.000 1）and 0.754（t = 5.641,P = 0.004）,each.Apelin and HOMA2-IR were also independent factors associated with children simple obesity,OR was 1.416（P=0.017）and 1.394（P=0.028）,respectively.Conclusions：Increased Apelin level in children with simple obesity may associated with insulin resistance.