摘要
目的:通过测定急性冠脉综合征(ACS)患者血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)水平,探讨其在ACS发生发展过程中的意义及对预后的影响。方法:采用放射免疫法分别检测22例不稳定性心绞痛(UA)、18例非ST段抬高型心肌梗死(NSTEMI)及28例ST段抬高型心肌梗死患者(STEMI)、11例健康者的血浆PRA、AngⅡ、Ald浓度,记录4周内所有患者的病情转归情况。结果:UA、NSTEMI、STEMI三组PRA、AngⅡ、Ald水平均明显高于健康对照组(P<0.05),组间相互比较均有统计学差异(P<0.05)。结论:肾素-血管紧张素-醛固酮系统活性水平与ACS的发生发展有关,并且与病情的严重程度呈正相关,对预后有重要的预测价值。
Objective：To investigate the clinical significance of renin-angiotensin-aldosterone system（RAAS） activity in the occurrence,development and prognosis of acute coronary syndrome（ACS）.Methods：The plasma concentrations of renin,angiotensin and aldosterone were measured by radioimmunoassay in 22 patients with unstable angina pectoris（UA）,18 with non-ST-segment elevation myocardial infarction（NSTEMI）,28 with ST-segment elevation myocardial infarction（STEMI） and 11 healthy subjects.The treatment outcome was recorded in 4 weeks.Results：The plasma renin,angiotensin and aldosterone levels in UA,NSTEMI and STEMI groups were significantly higher than those in healthy control group（P0.05）.There were significant differences in plasma renin,angiotensin and aldosterone levels among the groups（P0.05）.Conclusion：The plasma RAAS activity level is related with the occurrence and development of ACS and is positively related with the severity of disease,indicating significant predictive value for the prognosis of ACS patients.
出处
《西北国防医学杂志》
CAS
2010年第3期192-194,共3页
Medical Journal of National Defending Forces in Northwest China
