促红细胞生成素及受体在妊娠维持中的作用

Roles of Erythropoietin and Receptor in Pregnancy Maintenance

促红细胞生成素(EPO)是一类新发现的促血管生成因子,通过与其受体(EPOR)结合引发信号转导,具有促进血管生成、抗凋亡、抗缺氧作用,参与胎盘血管发生、肿瘤血管形成及转移等过程。EPO及EPOR在母-胎界面均有表达,对妊娠全过程起重要作用。妊娠过程中EPO/EPOR表达异常,可能与流产、子痫前期、胎儿生长受限等的发病有关。深入研究EPO在妊娠疾病中的作用,为妊娠疾病的诊断和治疗提供重要理论依据。

The erythropoietin （EPO） is a novel family of angiogenic factors that promote angiogenesis, antiapoptosis and anti-hypoxia when binding its receptor （EPOR）. The EPO participates in the development of placenta vessels, as well as the angiogenesis and tumor metastasis. EPO and its receptor expressed at reside maternal-fetal interface. Since EPO and its receptor are expressed throughout human gestation, it may play a pivotal role in pregnancy, and their abnormal regulation may be involved in spontaneous abortion, eclampsia and fetal growth restriction. Therefore, EPO in pregnancy may present a novel strategy for treatment of the pregnancy-related diseases.