促肾上腺皮质激素释放激素在早产中的研究

The Relationship Between Corticotropin-releasing Hormone and Preterm Labour

促肾上腺皮质激素释放激素(CRH)是由下丘脑视旁神经核分泌的一种41个氨基酸的神经肽,其不但在脑组织中广泛分布,也可来源于外周组织及人的胎儿胎盘单位。正常妊娠妇女血浆中CRH水平在妊娠晚期进行性升高,早产妇女CRH值在妊娠28周起显著高于正常对照组,血CRH在分娩后迅速下降,提示CRH与人类分娩的启动有密切关系。近年研究表明,CRH通过对胎儿下丘脑-垂体-肾上腺轴、母体子宫肌层及分娩相关的其他激素的作用,可能成为人类分娩启动的触发因子。CRH可有效干预分娩结局,达到控制早产的目的。就近年有关CRH在早产发病机制中的研究进展综述。

Corticotropin-releasing hormone （CRH） is a 41-amino-acid neuropeptide that fist identified in the hypothalamus. CRH is detectable in human＇s brain peripheral circulation and the maternal-fetal-placental unit. It has been noted that in the third trimester the CRH concentration in maternal plasma increased with advanced gestation, from the 28 menstrual week, the women in threatened prematurity groups were significantly higher than normal pregnancy, after the delivery, the CRH concentration decreased quickly. So we can make the conclusion that CRH may be an important factor in onset of delivery by hypothalamus-pituitary-adrenoeortex axis,maternal myometrium and other hormones. This article report the mechanisms of placental corticotrophin-releasing hormone （CRH） which is involved in the controlling of the onset of labour.