氯胺酮连续应用对犬的安全性研究

The safety of ketamine to dogs after continuous use

目的探讨长时间、连续应用氯胺酮对犬的安全性,为氯胺酮治疗狂犬病的临床应用奠定基础。方法给予不同剂量氯胺酮麻醉后观察犬的反应,肝、肾功能变化,观察犬的脑、肝、肾、肺、心肌等组织的病理学变化。结果氯胺酮麻醉1周后,犬的意识及健康状态良好,肝肾功能与空白对照组比较,差异无统计学意义(P>0.05);脑、肝、肾、肺、心肌等组织切片未见明显异常。结论长时间、连续应用氯胺酮对犬有较好的安全性和耐受性。

Objective To investigate the effect of the long and continuous use of ketamine on dogs,in order to pave a way for the continuous research of using ketamine in clinical application of rabies.Methods 40 dogs were divided into two groups randomly,group A for the control group,a total of 10 dogs;group B for the experimental group,a total of 30 dogs.Group B then were divided into three groups （B.1,B.2 and B.3）,B1 was the experimental group using different doses,a total of 10 dogs,B2 was the experimental group of maintenance using different doses,a total of 10 dogs,B3 was the experimental group of continuous maintenance,a total of 10 dogs.Recorded its clinical manifestations,time of induction and time of anesthesia.One week later,took intravenous blood of the dogs in the group of A and B3 to test the hepatic function and renal function separately.Putting the dogs in the group of B3 to death and do microanatomy examination of their brain,liver,kidney,lung and cardiac muscle.Results After a week,the conscious and healthy state of the experimental dogs were fine,hepatic function and renal function check against the control group,there was no statistic significance （P0.05）,microanatomy examination of their brain,liver,kidney,lung and cardiac muscle had not appeared to be obviously abnormal.Conclusion It is safe to dogs to use ketamine in long,continuous anaesthesia and dogs are able to bear.As ketamine can inhibite rabies virus,reduce the reaction of inflammation and protect brain,and so on,it is feasible to continue to carry out the research that ketamine is used in clinical treatment and prophylaxis of rabies.