血管内皮生长因子与子宫内膜异位症

Vascular Endothelial Growth Factor and Endometriosis

随着子宫内膜异位症(endometriosis,EMs)病因及发病机制研究的深入,备受大多数学者支持的内膜种植学说已无法合理解释绝大多数妇女经期存在经血逆流却只有少数发病这一现象。近年来,大量研究表明子宫内膜异位症的发生与种植部位新生血管的形成密切相关,认为经血逆流可能只是子宫内膜异位症发生的一个前提条件,而血供的建立和维持才是其发生的基本。而血管内皮生长因子作为目前所知作用最强的促血管生长因子,其与子宫内膜异位症的关系也因此成为人们研究的热点。

Among the endometriosis etiological studies,the theory of restrograde menstruation implantation is widely accepted.However,in recent years,scholars have found that restrograde menstruation was a common physiological phenomenon but the endometriosis incidence was much lower.And consequently they proposed that some other factors probably also play important roles in the progress of endometriosis.Currently,they found angiogenesis around the transplanted tissue was strongly associated with EMs and some of them hypothesized that menstrual backflow was only a preparation whereas the supply and maintenance of blood were major determinants.Therefore,vascular endothelial growth factor（VEGF） as the strongest angiogenic factor,has been becoming the main focus in the etiology of endometriosis.