不同温度20%甘露醇静脉滴注对闭角型青光眼急性发作患者的降眼压效果

The intraocular pressure lowering effect of 20% mannitol in different temperature on angle-closure glaucoma patients suffering acute attack

目的:探讨不同环境温度下静脉快速滴注不同温度20%甘露醇对降低眼压效果的影响。方法:将143例急性闭角型青光眼发作患者按照入院时间分为冬季组和夏季组,其中冬季组(12月～2月入院)77例,夏季组(7月～9月入院)66例,采用抽签法决定液体温度为25、30、35℃,分别记录输液前及输液后30min眼压值、心率及血压。结果:冬季组中30℃组与35℃组降眼压效果较25℃组效果好。在心率变化的比较中,35℃组心率、血压变化最小。夏季组3种不同温度20%甘露醇输液后降眼压效果无统计学差异。结论:冬季预热液体至35℃降眼压效果更加安全有效。

Objective： To explore the intraocular pressure lowering effect of 20% mannitol in different temperature on angle-closure glaucoma patients suffering acute attack in winter and in summer. Methods： One hundred and forty-three angle-closure glaucoma patients suffering acute attack were enrolled. The winter group included 77 patients, and the summer group included 66 patients. The temperature of 20% mannitol（25, 30 and 35℃ ）for each patient was randomly decided. The intraocular pressure, heart rate and blood pressure were recorded before and 30 minutes after the use of mannitol. Results： In winter group, the mannitol of 30 ℃ and 35 ℃ could get better intraoeular pressure lowering effect than that of 25 ℃ The mannitol of 35 ℃ induced smallest change of heart rate and blood pressure. In the summer group, the intraocular pressure lowering effect of 20% mannitol in three different temperatures had no significant difference. Conclusion： It would be safer and more effective for 20% mannitol heated to 35 ℃ in winter before use.