脑出血和脑梗死患者血浆NPY RIA和血脂分析的临床应用

Clinical Significance of Determination of Plasma NPY Levels and Serum Lipid Profile in Patients with Cerebral Hemorrhage and Cerebral Infarction

目的:为了探讨急性脑出血和脑梗死患者血中NPY和血脂分析的临床意义。方法:48例急性脑出血患者、46例脑梗死患者、35例正常对照组中血浆NPY应用RIA,血脂分析采用生化法。结果:48例脑出血患者和46例脑梗死患者血浆NPY水平明显高于35例正常对照组(P<0.05)。血脂分析中,48例脑出血患者血清TC、TG、LDL-C和LP(a)水平明显低于正常对照组(P<0.05～0.01),HDL-C明显高于正常对照组(P<0.05),ApoA和ApoB与正常对照组无明显差异;46例脑梗死患者血清TC明显高于正常对照组(P<0.01),HDL-C和LDL-C明显低于正常对照组(P<0.05～0.01),TG、ApoA、ApoB、LP(a)与正常对照组无明显差异(P>0.05)。结论:血浆NPY参与脑出血和脑梗死的发生和发展过程,它和血脂分析具有非常重要的临床应用价值。

Objective To study the clinical significance of changes of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction.Methods Plasma NPY levels（with RIA）and serum lipid profile（with biochemistry）were determined in ① 48 patients with acute cerebral hemorrhage ② 46 patients with acute cerebral infarction and ③ controls.Results Plasma NPY levels in both patients with cerebral hemorrhage and patients with cerebral infarction were significantly higher than those in controls（P0.05）.Lipid profile changes were more variable.In patients with cerebral hemorrhage,the serum TC,LDL-C and LP（a）levels were significantly lower than those in controls（P0.05~0.01）,the HDL-C levels were significantly higher（P0.05）and Apo-A and Apo-B levels were not much different from those in controls.In patients with cerebral infarction,the serum TC levels were significantly higher than those in controls（P0.01）but HDL-C and LDL-C levels were significantly lower（P0.05~0.01）.The TG,Apo-A,Apo-B and LP（a）levels were not much different from those in controls（P0.05）.Conclusion NPY played important roles in the development and pathogenesis of cerebral vascular accidents.Lipid profile changes was the basic etiological factor.