肺癌患者化疗前后血清IL-2、TNF-α和STNFR检测的临床意义

Clinical Significance of Measurement of Changes of Serum IL-2,TNF-α and STNFR Levels After Chemotherapy in Patients with Lung Cancer

目的:探讨了肺癌患者化疗前后IL-2、TNF-α和STNFR水平的变化及意义。方法:应用放射免疫分析和酶联法对36例肺癌患者进行化疗前后血清IL-2、TNF-α和STNFR的检测并与35名正常健康人作比较。结果:肺癌患者化疗前血清IL-2水平非常显著的低于正常人组(P<0.01),而TNF-α、STNFR水平明显高于正常人组(P<0.01),化疗后6个月在未复发的25例中明显下降,接近于正常人组,而复发组5例又回升至化疗前水平(P<0.05)。结论:检测肺癌患者血清中IL-2、TNF-α和STNFR含量的变化可作为诊断和疗效观察的参考。

Objective To explove the clinical significance of changes of serum IL-2,TNF-α and serum tumor hecrosis factor receptor（STNFR）levels after chemotherapy in patients with lung cancer.Methods Serum IL-2,TNF-α（with RIA）and STNFR（with ELISA）levels were determined in 36 patients with lung cancer both before and after chemotherapy as well as in 35 controls.Results Before chemotherapy,serum IL-2 levels in the patients were significantly lower than those in controls（P0.01）,while the serum TNF-α,STNFR levels were significantly higher（P0.01）.Six months after chemotherapy,in 25 patients without recurrence the levels were dropped markedly and approached those in controls.However in the 5 patients with recurrence,the levels increased again,approaching those before chemotherapy.Conclusion Determination of serum levels of IL-2,TNF-α and STNFR might be useful for diagnosis and predicting therapeutic effects after chemotherapy in patients with lung cancer.