子宫颈癌患者手术治疗前后血清IGF-Ⅱ、SCC和CYFRA21-1检测的临床意义

Clinical Significance of Measurement of Changes of Serum IGF-Ⅱ,SCC and CYFRA21-1 Levels After Operation in Patients with Carcinoma of Uterine Cervix

目的:探讨子宫颈癌患者手术治疗前后血清IGF-Ⅱ、SCC和CYFRA21-1水平的变化和临床意义。方法:应用放射免疫分析对31例子宫颈癌患者进行了手术治疗前后血清IGF-Ⅱ、SCC和CYFRA21-1的检测,并与35名正常健康妇女作比较。结果:子宫颈癌患者在手术治疗前血清IGF-Ⅱ、SCC和CYFRA21-1水平非常显著地高于正常妇女组(P<0.01),手术治疗1个月已接近正常。手术治疗6个月再测,未复发者仍在正常妇女水平,而复发者又恢复至手术前水平。结论:测定子宫颈癌患者血清中IGF-Ⅱ、SCC和CYFRA21-1水平的变化对患者的治疗和预后均有重要的临床价值。

Objective To explore the clinical significance of changes of serum IGF-Ⅱ,SCC and CYFRA21-1 levels after operation in patients with carcinoma uterine cervix.Methods Serum levels of IGF-Ⅱ,SCC and CYFRA21-1 were determined with RIA repeatedly in 31 patients with carcinoma of uterine cervix（before operation 1 month after operation and 6 month after operation）and once in 35 controls.Results Before operation,serum levels of IGF-Ⅱ,SCC and CYFRA21-1 in the patients were significantly higher than those in the controls（P0.01）.One month after operation all the serum levels were approaching normal.Six month later,the levels in the patients without recurrence remained normal.However,the levels in the 6 patients with recurrence returned to those before operation again.Conclusion Changes of serum IGF-Ⅱ,SCC and CYFRA21-1 levels are closely related to the tumor burden and may be of prognostic importance.