DM2肾病患者血浆ET-1、血清TGF-β_1和尿Alb检测的临床意义

Clinical Significance of Measurement of Changes of Plasma ET-1 and Serum TGF-β_1,Urinary Microalbuminuria (MAU) Levels in Patients with Type Ⅱ Diabetes

目的:探讨了2型糖尿病肾病(DN)患者血浆ET-1、血清TGF-β1和尿Alb水平的变化及临床意义。方法:应用放射免疫分析和酶联法对40例糖尿病无肾病和32例DN患者进行了血浆ET-1、血清TGF-β1和尿Alb进行了测定,并与35名正常健康人作比较。结果:DN组血浆ET-1、血清TGF-β1和尿Alb水平均显著地高于正常人组(P<0.01),NDN组与正常人组比较无显著性差异(P>0.05)。结论:血浆ET-1、血清TGF-β1和尿Alb含量随DN的发生以及严重程度逐渐增高,可作为早期诊断DN发生以及严重程度的指标,对监测早期DN的发生和病情发展程度有重要的临床价值。

Objective To study the clinical significance of changes of plasma ET-1 and serum TGF-β1,urinary microalbuminuria levels in patients with typeⅡ diabetes.Methods Plasma ET-1（with RIA）serum TGF-β1（with ELISA）microalbuminuria（with immune method）levels were determination in 40 cases of DM2 without nephropathy,32 cases of DM2 with nephropathy and 35 controls.Results The plasma ET-1,serum TGF-β1,microalbuminuria levels in diabetic patients with nephropathy were significantly higher than those in controls（P0.01）.The levels in patients without nephropathy were also higher than those in controls but not significantly（P0.05）.Conclusion Plasma ET-1 and serum TGF-β1,microalbuminuria levels increased gradually as the diabetic nephropathy got more severe.They could be used as senstitive markers for early diagnosis of development of diabetic nephropathy.