CNSI患者血浆中uPA及其受体(uPAR)的变化和临床意义

Clinical Significance of Detection of Changes of Plasma Urokinase-type Plasminogen Activator and its Receptor Levels in Patients with Central Nervous System Infection

目的:研究中枢神经系统感染(CNSI)患者血浆中尿激酶型纤溶酶原激活物(uPA)及其受体(uPAR)的变化及意义。方法:收集我院2006年10月～2008年7月CNSI住院患者69例,将CNSI病例分为病毒性脑炎组、结核性脑膜炎组、化脓性脑膜炎组,并设立对照组。用双抗体夹心酶联免疫法检测所有CNSI病例血浆中uPA及其受体(uPAR)水平。结果:化脓性脑膜炎组、结核性脑膜炎组uPA及其受体(uPAR)水平明显高于病毒组及对照组(P<0.01),血浆uPAR浓度改变与uPA同步,但uPAR升高水平高于uPA。结论:血浆中uPA及其受体(uPAR)水平在化脓性脑膜炎、结核性脑膜炎中升高,可为化脓性脑膜炎、结核性脑膜炎、病毒性脑炎的鉴别诊断提供更多的实验室依据。

Objective To study the clinical significance of changes of expression of plasma urokinase-type plasminogen activator（uPA）and urokinase-type plasminogen activator receptor（uPAR）in patients with central nervous system infection（CNSI）.Methods The expressions of plasma uPA and uPAR were detected with ELISA in 69 patients with various kinds of CNSI（viral encephalitis n=28,tuberculous meningitis n=18,and suppurative meningitis n=23）and 30 controls.Results The levels of plasma uPA and uPAR were significantly higher in patients with tuberculous and suppurative meningitis than those in the controls（P0.01）.Conclusion The levels of plasma uPA and uPAR were significantly increased in patients with tuberculous and suppurative meningitis,but not in patients with viral encephalitis.It may supply more laboratory evidence for differential diagnosis of viral from bacterial CNS infections.