1-巯甲基环丙基乙酸的合成研究

Synthesis of 1-(mercaptomethyl) Cyclopropane Acetic Acid

以1,1-环丙二甲醇为起始原料,经过关环,氰化,成酯,缩合,水解等5步反应制得药物孟鲁司特的关键中间体1-巯甲基环丙基乙酸,总收率49.5%。

1-（mercaptomethyl） cyclopropane acetic acid,the key intermediate of montelukast,was prepared from 1,1-Bis（hydroxymethyl） cyclopropane by ring-formation reaction,cyanation reaction,esterification reaction,aldol reaction,and hydrolytic reaction,with 49.5% overall yield.