轻度认知功能障碍淋巴细胞及炎症蛋白检测

Examinations of lymphocytes and inflammatory proteins in mild cognitive impairment

目的探讨MCI认知功能与淋巴细胞及炎症蛋白的关系。方法研究阿尔茨海默病(AD,36例)、轻度认知障碍(MCI,34例)及认知功能正常老年人(认知正常组,36人)的外周血淋巴细胞亚群、免疫球蛋白及炎性蛋白的差异。结果认知正常组、MCI组与AD患者的免疫球蛋白G(IgG)浓度中位数依次为10.5g/L、10.6g/L、13.1g/L(χ2=14.28,P<0.01);辅助性T淋巴细胞(TH)比例的中位数依次为41%、35%、37%(χ2=9.96,P<0.01);三组间差异有统计学意义。其中认知正常组与MCI组的IgG差异无统计学意义(Z=0.64,P=0.52),而AD组IgG水平高于MCI组(Z=3.26,P<0.01)和认知正常组(Z=3.22,P<0.01);认知正常组TH高于AD组(Z=2.55,P<0.05)和MCI组(Z=2.95,P<0.01),而MCI组与AD组的TH差异无统计学意义(Z=0.18,P=0.86)。结论 IgG可能在AD与MCI、认知功能正常者的鉴别方面具有重要意义;TH水平降低可能是认知功能受损的标志。

Objective：To investigate the relationship between inflammation and cognitive function.Methods：The differences of peripheral blood lymphocyte subsets,immunoglobulin and inflammatory protein among Alzheimer＇s disease （AD,n=36）,mild cognitive impairment （MCI,n=34） and healthy elderly （n=36） were examined.Results：The median levels of immunoglobulin G （IgG） and the percentages of helper T lymphocytes （TH） were 10.5g/L,10.6g/L,13.1g/L （χ2=14.28,P0.01） and 41%,35%,37% （χ2=9.96,P0.01）,respectively,among healthy elderly,MCI and AD,in that order.There were statistically significant among three groups.There was no statistically significant difference in IgG between healthy elderly and MCI （Z=0.64,P=0.52）.The level of IgG was higher in AD than in MCI （Z=3.26,P0.01） and healthy elderly （Z=3.22,P0.01）.The level of TH was higher in healthy elderly than in AD （Z=2.55,P0.05） and MCI （Z=2.95,P0.01）.There was no statistically significant difference in TH between MCI and AD （Z=0.18,P=0.86）.Conclusion：IgG may play an important role in differentiating healthy elderly,MCI and AD.Reduction in TH level could be a sign of cognitive impairment.