Bag-1蛋白在口腔鳞状细胞癌中的表达及临床意义

Expression and Clinical Significance of Bag-1 proteins in Oral Squamous Cell Carcinoma

目的:检测Bag-1蛋白在口腔鳞状细胞癌(Oral squamous cell carcinoma,OSCC)中的表达,探讨其在不同分化的OSCC中表达的差异及其临床意义。方法:应用免疫组织化学法S-P法检测52例OSCC及20例正常的舌黏膜组织中Bag-1蛋白的表达,数据采用SPSS13.0统计软件进行χ2检验。结果:Bag-1蛋白在病理分级的高分化组阳性表达率为50.00%、中分化组阳性表达率为76.19%、低分化组阳性表达率为93.33%,三者之间对比有显著性差异(P<0.05),与正常对照组有显著性差异(P<0.01);在临床分期为早期(Ⅰ级+Ⅱ级)组中阳性表达率为55.55%,晚期(Ⅲ级+Ⅳ级)组中阳性表达率为82.35%,二者之间存在显著性差异(P<0.05)。结论:Bag-1蛋白的表达与OSCC的病理分级和临床发展关系密切,并且检测该指标有助于OSCC的早期诊断。

Objective：To detect the expression of Bag-1 proteins in human oral squamous cell carcinoma（OSCC）and explore its clinicopathological significance.Methods：The expression of Bag-1 proteins in 52 cases of OSCC and 20 cases of normal oral squamous tissue was detected by immunohistochemistry using S-P staining.The correlation of each score according to the intensity and percentage of labeled cells or intercellular substnace with relevant clinical date was statistically analyzed by SPSS13.0 soft with χ2 test.Results：The postive rates of Bag-1 proteins in well differentiated OSCC group was 50.00%,that in moderately differentiated OSCC group was 76.19% and in poorly differentiated OSCC group was 93.33%,There were significant differences of Bag-1 proteins postive rates in different grades（P0.05）,and it was significantly higher in OSCC than in normal oral mucosal tissue（P0.01）.The postive rates of Bag-1 proteins in clinical early stage group was 55.55% and in clinical advanced stage group was 82.35%.There was significant difference between two stages（P0.05）.Conclusion：There was significant correlation between the expression of Bag-1 proteins and OSCC genesis and development,and the expression of Bag-1 proteins detected administers to diagnose early.