兰索拉唑联合吗丁啉治疗反流性食管炎48例临床分析

Clinical analysis of lansoprazole combined with motilium in the treatment of reflux esophagitis

目的探讨兰索拉唑联合吗丁啉治疗反流性食管炎的疗效。方法将我院诊治的90例反流性食管炎患者随机分为两组,对照组42例,采用雷尼替丁+吗丁啉治疗;观察组48例,采用兰索拉唑+吗丁啉治疗,两组均8周为1个疗程。结果观察组的显效率为89.6%,高于对照组的69.0%(χ2=5.90,P<0.05);两组不良反应发生率分别为8.3%、11.9%,差异无统计学意义(χ2=0.32,P>0.05)。结论兰索拉唑联合吗丁啉治疗反流性食管炎疗效满意,且安全性好,值得临床推广应用。

Objective To explore the effect of lansoprazole combined with motilium in the treatment of reflux esophagitis.Methods 90 patients with reflux esophagitis in our hospital were randomly divided into two groups.The control group（n = 42）was treated with Ranitidine and motilium and the observation group（n = 48）with lansoprazole and motilium.The course of treatment of both groups was 8 weeks on average.Results The excellence efficiency of the two groups was 89.6% and 69.0% respectively（χ2 = 5.90,P 0）,and adverse reaction rate of the two groups was 8.3% and 11.9%.The differences had no statistical significance（χ2 = 0.32,P 0.05）.Conclusion Lansoprazole combined with Motilium in the treatment of reflux esophagitis can give satisfactory curative effect and safety.