416例药品不良反应报告分析

Analysis of 416 ADR reports in our hospital

目的了解我院药品不良反应(ADR)发生的特点及规律。方法对我院2007年5月-2009年8月上报的416例ADR报告进行分类统计分析。结果 60岁以上的患者ADR发生率较高,占28.85%;静脉给药引起的ADR比例最高,占62.74%;ADR累及的器官和系统最常见的为皮肤及附件损害,占43.75%;抗菌药物引起的ADR居首位,占45.43%。结论全面加强药物不良反应的监测及评价工作,减少或避免ADR的重复发生,确保患者用药安全。

Objective To investigate the characteristics and regularity of the adverse drug reaction（ADR）occurred in our hospital.Methods A total of 416 ADR cases collected in our hospital from May 2007 to August 2009 were analyzed statistically.Results 28.85% of the ADR occurred in patients over the age of 60,and 62.74% were induced by intravenous administration.The most common manifestation of ADR was lesion of skin and its appendages.The antibacterials accounted for 45.43% in all the drugs.Conclusion ADR monitoring and appraising work should be emphasized to reduce or avoid the recurrence of ADR,ensure safety of patients′ drug use.