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胰腺内分泌肿瘤的外科治疗 被引量：4

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摘要 胰腺内分泌肿瘤（pancreatic endocrine neoplasm，PEN）约占全部胰腺肿瘤的2％～4％，年发病率约为1／10000。根据有无临床症状及分泌的激素水平可分为功能性和无功能性PEN。前者以胰岛素瘤最为常见，胃泌素瘤次之，胰高血糖素瘤、血管活性肠肽瘤、生长抑素瘤等较为罕见；后者约占胰腺内分泌肿瘤的30％～50％。另有约10％～20％的患者合并多发性内分泌肿瘤（multiple endocri neneoplasm，MEN）。除胰岛素瘤约10％为恶性外，其他PEN约60％～80％为恶性，且发现时多已存在肝脏转移。
作者 廖泉 赵玉沛
机构地区 中国医学科学院北京协和医学院北京协和医院基本外科
出处 《中华内分泌外科杂志》 CAS 2010年第3期145-147,共3页 Chinese Journal of Endocrine Surgery
关键词 胰腺内分泌肿瘤 外科治疗 neoplasm 多发性内分泌肿瘤 血管活性肠肽瘤 胰高血糖素瘤 无功能性 胰岛素瘤
分类号 R735.9 [医药卫生—肿瘤]
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参考文献18

  • 1Fitzgerald TL,Hickner ZJ,Schmitz M,et al.Changing incidence of pancreatic neoplasms:a 16-year review of statewide tumor registry[J].Pancreas,2008,37(2):134-138.
  • 2Plockinger U,Rindi G,Arnold R,et al.Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours.A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS)[J].Neuroendocrinology,2004,80 (6):394-424.
  • 3Halfdanarson TR,Rubin J,Farnell MB,et al.Pancreatic endocrine neoplasms:epidemiology and prognosis of pancreatic endocrine tumors[J].Endocr Relat Cancer,2008,15(2):409-427.
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  • 6胰腺内分泌肿瘤的诊断和外科治疗指南（讨论稿）[J].中华外科杂志,2009,47(5):339-341. 被引量：14
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二级参考文献17

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  • 8Norton JA, Fraker DL, Alexander HR, et al. Surgery increases survival in patients with gastrinoma. Ann Surg,2006,244:410-419.
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  • 10House MG, Schulick RD. Endocrine tumors of the pancreas. Curr Opin Oncol,2006,18 : 23-29.

共引文献13

同被引文献30

引证文献4

二级引证文献6

中华内分泌外科杂志
2010年 第3期

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