α-干扰素+丝裂霉素C膀胱灌注预防膀胱癌术后复发的疗效观察

Observation of the effect of interferon-alpha and mitomycin-C by bladder instillation to treat bladder cancer on prevention the recurrence after operation

目的分析浅表性膀胱癌患者行经尿道膀胱肿瘤电切术(TURBT)后分别采用α-干扰素+丝裂霉素C和卡介苗进行膀胱灌注预防肿瘤复发的疗效。方法将64例浅表性膀胱癌术后患者随机分为观察组34例和对照组30例。观察组采用α-干扰素+丝裂霉素C治疗,对照组给予卡介苗作膀胱灌注,观察其不同疗效。结果所有病例随访12～24个月,平均18个月。观察组复发率为11.76%低于对照组的16.67%,差异有统计学意义(P<0.05),且不良反应小。结论α-干扰素+丝裂霉素C疗效优于卡介苗,且不良反应小,耐受性好,可以作为临床一线用药。

Objective To evaluate the effect of interferon-alpha ＋mitomycin-C and Bacille Calmette Guerin（BCG）by bladder instillation to treat superficial bladder cancer.Methods 64 patients with superficial bladder cancer were randomly divided into observation group of 34 cases and the control group of 30 cases.Interferon-alpha ＋mitomycin-C by bladder instillation was used in the observation group,BCG was used in the control group.The effects were observed.Results All patients were followed up 12～24 months,average of 18 months.The recurrence of bladder cancer in observation group was 11.76% lower than 16.67% in the control group,the difference was statistically significant（P0.05）,and had fewer adverse reactions.Conclusion The effect of interferon-alpha＋mitomycin-C is superior to BCG,and has low side effect,better tolerated,so it is the first choice in clinical bladder instillation.