胰岛素样生长因子受体1在乳腺癌组织中的表达及意义

Expression of insulin-like growth factor receptor 1 in breast cancer and its clinical significance

目的:探讨胰岛素样生长因子受体1(IGFR-1)在乳腺良、恶性疾病组织中的表达及与各临床参数的关系。方法:采用免疫组织化学法检测IGFR-1在34例乳腺浸润性导管癌和28例乳腺良性疾病组织中的表达率。结果:IGFR-1在乳腺癌组织中的表达率为76.5%,明显高于其在良性乳腺疾病组织中的表达率44.1%(P<0.05);IGFR-1在乳腺癌组织中的表达水平与雌激素受体(ER)、孕激素受体(PR)呈正相关(r=0.56,P<0.01;r=0.51,P<0.01);与腋下淋巴结转移及临床分期无关(r=0.31,P>0.05;r=0.18,P>0.05)。结论:在大多数乳腺癌组织中表达的IGFR-1可作为标志物用于肿瘤的诊断和预后判断,并可作为乳腺癌靶向治疗的新靶点。

Objective To examine the expression of insulin-like growth factor receptor 1（IGFR-1） in breast cancer tissue and its relationship with clinical parameters. Methods The expressions of IGFR-1 were detected in paraffin-embedded specimens from 34 patients with breast cancer and 28 controls with surgically proven benign breast disease with immunohistochemical method. Results The expression rate of IGFR-1 in breast cancer tissue was 76.5%,it was significantly higher than that in benign tissue （44.1%）（P0.05）.In cancer group,there was positive correlation between the expression level of IGFR-1 and estrogen receptor （ER） and progesterone receptor （PR） （r=0.56,r=0.51,P0.01）;there was no significant relationship between IGFR-1 expression and armpit lymphatic node metastasis and clinical stages （r=0.31,r=0.18,both P0.05）.Conclusion IGFR-1 can express in most of the breast cancer tissues which could be used as a biomarker for diagnosis and prognosis of breast cancer and a new target for treatment of breast cancer.