摘要
目的 探讨血清白细胞介素-6(IL-6)测定在Graves病患者中的临床意义.方法 用ELISA法测定75例Graves病患者的IL-6,分析IL-6与其他功能指标(如T3、T4等)、免疫指标(如TRAb)的相关性,并与健康对照组比较.结果 IL-6水平Graves病组为(1.84 ±1.58)ns/L,健康对照组为(1.28 ±0.46)ng/L,2组比较差异有统计学意义(t=2.55,P〈0.05).相关分析发现,IL-6与T3(r=0.55)、T4(r=0.40)、FT4(r=0.36)、FT3(r=0.35)及TRAb(r=0.47)正相关(P均〈0.05),与TSH负相关(r=0.58,P〈0.05).结论 IL-6可以作为Graves病的免疫紊乱及甲状腺功能的良好评价指标.
Objective To study the clinical value of serum FL-6 detection in patients with Graves. Methods The level of IL-6 was detected in 75 Graves patients and controls with ELISA, the correlation between IL-6, other function parameter (T3, T4, etc.) and immune indicators (TRAb) were analyzed. Results The level of IL-6 in Graves patients was(1. 84 ±1. 58) ng/L, which was significantly higher than the healthy controls(l. 28 ±0.46)ng/L (t=2.55,P〈0.05).IL-6 was positive correlation with T3(r =0. 55) ,T4(r =0. 40) ,FT4(r =0. 36) , FT3(r = 0. 35)and TRAb(r = 0. 47) (P 〈0. 05)and was negative correlation with TSH(r= -0. 58, P 〈 0. 05). Conclusions IL-6 can be used as a good index of immune derangement and thyroid function disorders in Grave patients.
出处
《中国综合临床》
2010年第6期603-605,共3页
Clinical Medicine of China