摘要
目的 探讨血清白细胞介素-6（IL-6）测定在Graves病患者中的临床意义.方法 用ELISA法测定75例Graves病患者的IL-6,分析IL-6与其他功能指标（如T3、T4等）、免疫指标（如TRAb）的相关性,并与健康对照组比较.结果 IL-6水平Graves病组为（1.84 ±1.58）ns/L,健康对照组为（1.28 ±0.46）ng/L,2组比较差异有统计学意义（t=2.55,P〈0.05）.相关分析发现,IL-6与T3（r=0.55）、T4（r=0.40）、FT4（r=0.36）、FT3（r=0.35）及TRAb（r=0.47）正相关（P均〈0.05）,与TSH负相关（r=0.58,P〈0.05）.结论 IL-6可以作为Graves病的免疫紊乱及甲状腺功能的良好评价指标.
Objective To study the clinical value of serum FL-6 detection in patients with Graves. Methods The level of IL-6 was detected in 75 Graves patients and controls with ELISA, the correlation between IL-6, other function parameter （T3, T4, etc.） and immune indicators （TRAb） were analyzed. Results The level of IL-6 in Graves patients was（1. 84 ±1. 58） ng/L, which was significantly higher than the healthy controls（l. 28 ±0.46）ng/L （t=2.55,P〈0.05）.IL-6 was positive correlation with T3（r =0. 55） ,T4（r =0. 40） ,FT4（r =0. 36） , FT3（r = 0. 35）and TRAb（r = 0. 47） （P 〈0. 05）and was negative correlation with TSH（r= -0. 58, P 〈 0. 05）. Conclusions IL-6 can be used as a good index of immune derangement and thyroid function disorders in Grave patients.
出处
《中国综合临床》
2010年第6期603-605,共3页
Clinical Medicine of China
