摘要
目的:观察清热解毒方对腹腔感染大鼠血清内毒素及细胞因子水平的影响。方法:Wistar大鼠随机分为4组:对照组、模型组、清热解毒方组、头孢克肟组,ig1次,给药30 min后大肠杆菌ip造成大鼠急性细菌性腹膜炎模型,于6,12,18,24 h后分别检测各组动物血浆内毒素,肿瘤坏死因子α(TNF-α),IL-6,IL-10水平。结果:造模后模型组大鼠血清内毒素,TNF-α,IL-6,IL-10较对照组明显升高(P<0.01),清热解毒方组与头孢克肟组上述指标较模型组明显降低。结论:清热解毒方能有效降低大肠杆菌腹腔感染大鼠血清内毒素及TNF-α,IL-6,IL-10水平。
Objective:To explore the effects of Qingre Jiedu Fang(QRJD Fang) on the secretion of endotoxin,TNF-α,IL-6 and IL-10 in intra-abdominal infection rats.Method:After giving 30 min of i.g QRJD Fang or cefi xime(ANT),rat model of acute bacterial peritonitis was set up.Endotoxin,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-10(IL-10) in serum were determined respectively in 6h,12h,18h,24h after acute bacterial peritonitis in the four groups(control group,model,QRJD Fang group,ANT group).Result:Compared with the control group,serum endotoxin,TNF-α,IL-6 and IL-10 in the model were increased obviously(P 0.01),while the indexes in QRJD Fang group and ANT group were decreased(P 〈0.01 or P〈 0.05).Conclusion:QRJD Fang could obviously inhibit the secretion of inflammatory cytokints,such as endotoxin,TNF-α,IL-6 and IL-10 in the acute intra-abdominal infection rats.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第6期176-178,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
天津市科技攻关计划重大科技项目(05YFGDSFO2600)
关键词
清热解毒方
腹腔感染
内毒素
细胞因子
Qingre Jiedu Fang
intra-abdominal infection
endotoxin
cytokine