栀子环烯醚萜苷治疗脑缺血损伤的作用机制研究

Progress in Studies on Mechanism of Gardenia Iridoid Glycosides for Cerebral Ischemic Injury

目的:探讨近几年来栀子环烯醚萜苷治疗脑缺血损伤的作用机制,为栀子环烯醚萜苷类成分的进一步研究和应用提供参考。方法:查阅国内外相关文献并进行归纳、总结。结果:环烯醚萜苷类成分是栀子药材的主要化学成分。研究表明,它不仅有明显的保肝利胆、解热、镇静等作用,而且对缺血性脑损伤亦有保护作用。关于栀子环烯醚萜苷类成分对缺血性脑损伤的保护作用研究较多,其作用机制是多方面的。结论:栀子环烯醚萜苷治疗脑缺血损伤的作用机制有待进一步研究。

Objective：To review the progress in studies on mechanism of gardenia iridoid glycosides for treatment of cerebral ischemic injury,so as to provide more information on gardenia iridoid glycosides for further research and application.Method：The literatures published home and abroad in recent years were consulted and summarized.Result：Gardenia iridoid glycosides are the main chemical components in Fructus Gardeniae.Modern studies show that gardenia iridoid glycosides not only have protective effects in liver gallbladder,antipyretic,sedative and other effects,but also have protective effects against ischemic brain injury.Currently there are more studies about gardenia iridoid glycosides against ischemic brain injury,and the mechanism is multifaceted.Conclusion：More studies are needed on the mechanism of gardenia iridoid glycosides for treatment of cerebral ischemic injury.