防风化学成分的研究

Chemical constituents of roots of Saposhnikovia divaricata

目的：对防风Saposhnikovia divaricata未抽花茎的干燥根的化学成分进行研究。方法：采用硅胶柱色谱方法进行分离、纯化,IR,UV,MS和NMR等谱学方法进行结构鉴定。结果：从防风甲醇提取物中得到18个化合物,分别鉴定为3′-O-当归酰亥茅酚（1）,异香柑内酯（2）,欧前胡素（3）,二十五烷酸（4）,川白芷内酯（5）,紫花前胡素（6）,5-甲氧基-7-（3,3-二甲基烯丙氧基）-香豆素（7）,紫花前胡醇当归酰酯（8）,花椒毒酚（9）,香柑内酯（10）,杨芽黄素（11）,东莨菪素（12）,亥茅酚（13）,防风色原酮（14）,升麻素（15）,亥茅酚苷（16）,5-O-甲基维斯阿米醇苷（17）,升麻苷（18）。结论：化合物2,6~8和11为首次从防风中得到。1,13~18等为色原酮类化合物;化合物2,3,5~10,12等为香豆素类化合物;4为脂肪酸类化合物;11为黄酮类化合物。

Objective： To study the chemical constituents in the dried roots of Saposhnikovia divaricata.Method： The chemical constituents were isolated by various column chromatographic methods and structurally elucidated by IR,UV,MS and NMR evidences.Result： Eighteen compounds were obtained and identified as 3′-O-angeloylhamaudol（1）,isobergapten（2）,imperatorin（3）,pentacosane acid（4）,anomalin（5）,decursin（6）,5-methoxy-7-（3,3-dimethylallyl-oxy）coumarin（7）,decursinol angelate（8）,xanthotoxin（9）,bergapten（10）,tectochrysin（11）,scopoletin（12）,hamaudol（13）,ledebouriellol（14）,cimifugin（15）,sec-O-glucosylhamaudol（16）,4′-O-β-D-glucosyl-5-O-methylvisamminol（17）,and prim-O-glucosylcimifugin（18）.Conclusion： Compounds 2,6-8,and 11 were isolated from the roots of S.divaricata for the first time.Compounds 1 and 13-18 were chromones,2,3,5-10 and 12 were coumarins,4 was fatty acid,and 11 was flavonoid.