空腹血糖相关危险因素十年变化趋势

Ten-year changes in the relevant risk factors for fasting blood glucose

目的:了解空腹血糖相关危险因素随时间变化趋势,以便针对性的制定有效的糖尿病预防策略。方法:利用同一地区相隔十年两次横断面调查所收集数据,按空腹血糖程度不同进行分组:空腹血糖正常组(空腹血糖<6.1mmol/L)、空腹血糖升高组(空腹血糖≥6.1mmol/L)。比较两次调查及每次调查各组间差异。比较分析两次调查空腹血糖相关危险因素差异及变化趋势。结果:(1)1983-1984年血糖升高占被调查人数1.06%(75/7066),1993-1994年血糖升高占被调查人数5.55%(353/6362)。(2)多元线形回归分析:1983-1984年甘油三酯(TG)、总胆固醇(TG)、年龄进入方程。1993-1994年:除上述因素外平均收缩压(SBP)、平均舒张压(DBP)、体重指数(BMI)、身高腰围比(Whtr)、腰臀围比(WHR)、高密度脂蛋白(HDL)也进入方程。(3)logistic多因素非条件回归分析显示1983-1984年有年龄、TC、TG进入方程;1993-1994年除上述因素外还有糖尿家族病史、职业、血压、Whtr进入方程。结论:空腹血糖危险因素随时间的迁移有明显的增多细化趋势。增龄、血脂紊乱为空腹血糖升高持续稳定的危险因素;高血压、Whtr不是20世纪80年代空腹血糖升高的主要危险因素。

Objective To develop effective diabetes prevention strategies, we explore the changes in the relevant risk factors for fasting blood glucose with time.Methods The data from two cross-sectional surveys apart from ten years were used.The subjects were assigned to normal glucose group（glucose 6.1 mmol / L） or elevated glucose group（glucose ≥ 6.1 mmol / L） based on the levels of fasting blood glucose.The differences in two surveys and the differences between two groups in each survey were compared.The differences and changes in the relevant risk factors for fasting blood glucose were analyzed.Results 75 of 7 066 subjects（1.06%） had an elevated glucose level during 1983-1984 and 353 of 6 362 subjects（5.55%） had an elevated level during 1993-1994.Multiple linear regression showed triglyceride（TG）, total cholesterol（TC）, and age entered the equation during 1983-1984.Besides the above-mentioned variables, average systolic blood pressure（SBP）, mean diastolic blood pressure（DBP）, body mass index（BMI）, waist-height ratio（Whtr）, waist-hip ratio（WHR）, high-density lipoprotein（HDL ） also entered the equation.Logistic multivariate unconditional regression showed age, TC, and TG entered the equation during 1983-1984;apart from the three variables, family history of diabetes, occupation, blood pressure, and Whtr entered the equation.Conclusions The risk factors for fasting blood glucose have a marked trend of increase with time.Increasing age and lipid disorders are the continuously stable risk factors for elevated fasting blood glucose.Hypertension and Whtr were not main risk factors of elevated fasting blood glucose in 1980s.