刺柳珊瑚Echinogorgia sp.中的三个神经酰胺

Three ceramides from gorgonian Echinogorgia sp.

目的从刺柳珊瑚中寻找新化合物。方法采自南中国海域的刺柳珊瑚Echinogorgiasp.经色谱柱分离得到3个同系列的神经酰胺。结果通过波谱分析及化学转化等方法确定了其化学结构分别为(2S,3S,4R)-2-N-(1,3,4-三羟基-正二十烷基)-正十六碳酰胺(1)、(2S,3S,4R)-2-N-(1,3,4-三羟基-正二十烷基)-正十七碳酰胺(2)和(2S,3S,4R)-2-N-(1,3,4-三羟基-正二十烷基)-正十八碳酰胺(3)。结论 3个化合物均是首次从该物种中分离得到,其中化合物2是新化合物,命名为刺柳珊瑚酰胺(echinogoriamide)。

Objective To find new compound from gorgonian.Methods Three ceramides have been isolated from the South China Sea gorgonian Echinogorgia sp.by silica gel column chromatography.Results Their structures were established as（2S,3S,4R）-N-[2-（1,3,4-trihydroxyicosan-2-yl）]-hexadecanamide（1）,（2S,3S,4R）-N-[2-（1,3,4-trihydroxyicosan-2-yl）]-heptadecanamide（2）,and（2S,3S,4R）-N-[2-（1,3,4-trihydroxyicosan-2-yl]-octadecanamide（3） by spectroscopic methods and chemical conversion.Conclusion It is the first time to report the three chemical compounds from coral Echinogorgia sp.and compound 2 is a new compound.