祁州漏芦根的化学成分研究

Chemical constituents of Rhaponticum uniflorum

目的研究菊科植物祁州漏芦Rhaponticum uniflorum根的化学成分。方法采用系统溶剂提取法结合各种色谱分离技术、理化性质和光谱数据鉴定结构。结果从祁州漏芦根里分离得到11个单体成分,其中6个噻吩类,2个甾醇类,1个五环三萜类,2个长链脂肪酸类。结构鉴定为牛蒡子醛（arctinal,1）、牛蒡子酮-b（arctinone-b,2）、7-chloroarctinone b（3）、5-methoxyl-5′-（1-propinyl）-2,2′-dithiophene（4）、β-谷甾醇（β-sitosterol,5）、豆甾醇（stig-masterol,6）、齐墩果酸（oleanolic acid,7）、棕榈酸（pal mitic acid,8）、E-7,9-diene-11-methenyl pal mitic acid（9）、5-me-thoxyl-2,2′-dithiophene（10）和5-（4-acetoxyl-1-butynyl）-2,2′-dithiophene（11）。结论化合物4和8-11是首次从该属植物中分离得到。

Objective To study the chemical constituents in the root of Rhaponticum uniflorum.Methods Separation and purification were performed on silica gel and prep-TLC.Their structures were elucidated on the basis of physicochemical and spectral analyses.Results Eleven compounds were isolated and identified as arctinal（1）,arctinone-b（2）,7-chloroarctinone b（3）,5-methoxyl-5′-（1-propinyl）-2,2′-dithiophene（4）,β-sitosterol（5）,stigmasterol（6）,oleanolic acid（7）,palmitic acid（8）,E-7,9-diene-11-methenyl palmitic acid（9）,5-methoxyl-2,2′-dithiophene（10）,and 5-（4-acetoxyl-1-butynyl）-2,2′-dithiophene（11）,respectively.Conclusion Compounds 4,8-11 are isolated from the plants of Rhaponticum Cass.for the first time.