L-薄荷基甲醛的合成

Synthesis of L-menthylformaldehyde

薄荷基氯格氏试剂与N,N-二甲基甲酰胺(DMF)在四氢呋喃中反应,一步合成了L-薄荷基甲醛。重点探讨了物料比、反应温度和反应时间对反应收率的影响。最优的反应条件是薄荷基氯格氏试剂与DMF以1∶1.2的摩尔比在20℃反应4h。在最优反应条件下,产率为42.6%,产物没有立体异构体。

L-menthylformaldehyde was synthesized by the reaction of the Grignard reagent derived from menthyl chloride with N,N-dimethylformamide（DMF）in tetrahydrofuran by one-step process.The influence of the material ratio,reaction temperature and reaction time on the yield of the product had been investigated.The optimal reaction condition was the Grignard reagent reaction with 1.2 equivalent of DMF at 20 ℃ for 4 hours.Under the optimal reaction condition,the yield was 42.6% and no stereoisomer yielded.