二尖瓣球囊成形术前后血浆血管活性肠肽变化的观察

Changes of plasma vasoactive intestive peptide before and after percutaneous balloon mitral valvuloplasty

对３０例患者二尖瓣球囊成形术（ＰＢＭＶ）前后的血浆血管活性肠肽（ＶＩＰ）进行检测，并分析ＶＩＰ与心率（ＨＲ）、心输出量（ＣＯ）、心脏指数（ＣＩ）、平均右房压（ＭＲＡＰ）、平均左房压（ＭＬＡＰ）、平均二尖瓣跨瓣压差（ＭＰＧ）和二尖瓣口面积（ＭＶＡ）的关系。结果提示：术后血浆ＶＩＰ水平从１５．９３±４．４６ｐｍｏｌ／Ｌ（与对照组５．９１±２．８５ｐｍｏｌ／Ｌ比较，Ｐ＜０．００１）降到８．０２±３．５８ｐｍｏｌ／Ｌ（与术前比较Ｐ＜０．００１，与对照组比较Ｐ＜０．０５）；血浆ＶＩＰ水平与ＨＲ、ＭＲＡＰ、ＭＬＡＰ、ＭＰＧ呈显著正相关，与ＣＯ。

Plasma vasoactive intestive peptide (VIP) level was measured in 30 patients with mitral stenosis before and after percutaneous balloon mitral valvuloplasty (PBMV), and the relations between the changes in VIP, heart rate (HR), cardiac output (CO), Cardiac index(CI), mean right atrial pressure (MRAP), mean left atrial pressure (MLAP), mean transmitral ptessure gradient (MPG) and mitral valve area (MVA) were analysed After PBMV, VIP level decreased from 15 93±4 46pmol/L( P <0 001 vs control group) to 8 02±3 58pmol/L( P <0 001 vs befored PBMV, P <0 05 vs contral group) There was a significant positive correlation between the VIP level and HR, MRAP, MLAP, MPG; and a significant negative correlation between VIP level and CO, MVA