女性糖尿病患者性激素水平变化与高胰岛素血症关系探讨

Correlation between the levels of sex hormone and hyperinsulinemia in women with Ⅱ type DM

对３６例绝经前期和４４例绝经后期Ⅱ型糖尿病非胰岛素治疗患者的雌二醇、睾酮、血浆空腹胰岛素水平进行放免测定，结果显示：绝经后组胰岛素敏感性指数显著低于绝经前组，而空腹胰岛素水平及高胰岛素血症的百分率显著高于绝经前组。相关分析表明：雌二醇与胰岛素呈显著负相关（ｒ＝－０．２６８２；Ｐ＜０．０５），与胰岛素敏感性指数显著正相关（ｒ＝０．２４７６；Ｐ＜０．０５）。

The estradiol (E 2), testoterone(T), plasma fast insulin (FIns) were measured by radioimmunoassay in 36 premenopause and 44 postmenopause patients with Ⅱ type DM who no insulin treated The results showed that insulin sensitivity index(ISI) in postmenopause were significantly lower than those in premenopause, While FIns, the prevalence of hyperinsulinemia in postmenopause were markedly higher than those in premenopause correlation analysis demostrated that E 2 was negatively related to FIns (r=-0 2682; P <0 05) and positively related to ISI (r=0 2476; P <0 05)。 These results indicated that sex hormone was related to hyperinsulinemia