鼻咽癌中p21^(ras)的表达及其与淋巴结转移的关系

Expression of p21 ras and its Relation to Lymph Node Metastases in Nasopharyngeal Carcinoma

目的：探讨ｐ２１ｒａｓ蛋白在鼻咽癌组织中的过表达及其与淋巴结转移的关系。方法：应用免疫组织化学方法（ＬｓＡＢ法）检测６２例未治疗的鼻咽癌活检组织，其中分化型非角化癌１５例，未分化癌４７例；未转移组２４例，转移组３８例。结果：ｐ２１ｒａｓ在鼻咽癌组织中过表达的总阳性率是５６％，分化型非角化癌３３％，未化分癌６４％，两者间有显著性差异，未转移组３８％，转移组６８％，两组间有显著性差异。结论：ｐ２１ｒａｓ蛋白过表达与有无伴颈淋巴结转移呈正相关，与鼻咽癌分化程度呈负相关，预示ｐ２１ｒａｓ可作为判断鼻咽癌预后的标记之一。

s Objecctives: To study p21 ras protein overexpressions in the tissues of nasopharyngeal carcinomas (NPC) and its relation with lymph node metastases. Methods: p21 ras protein overexpressions were detected by immunohistochemical method (LsAB method) in 62 specimens of NPC and in 25 normal nasopharyngeal mucosa as controls. Among the cancers 62, 15 were of the differentiated non keratinized carcinomas (DNKC), 47 undifferentiated carcinomas (UC); 24 of the NPC without metastasis to the cervical lymph nodes (nmNPC), 38 with metastasis of cervical lymph nodes (mNPC). Results: p21 ras protein overexpressions were demonstrated in 35 of 62 cases (56%). There were significant differences of the overexpressions between DNKC and UC or nmNPC and mNPC (P<0 05). Conclusions: p21 ras protein overexpressions in NPC were related to the metastasis of cervical lymph node and the degree of differentiation of the tumor cells.