原发性头痛患者血浆组织型纤溶酶原激活物及其抑制物活性变化的研究

Studies on the changes of activites of tissue-type plasminogen activitor and its rapid inhibitor in plasma in patients with idiopathic headache

本研究应用发色底物法（ＣＳ）测定了两类原发性头痛：偏头痛及紧张性头痛患者血浆组织型纤溶酶原激活物（ｔ－ＰＡ）及其快速抑制物（ＰＡＩ－１）活性的变化规律。结果发现：两类原发性头痛患者血浆ｔ－ＰＡ活性变化不明显，而ＰＡＩ－１ 活性均明显增高，说明两类原发性头痛患者均存在血管内皮功能损伤及血浆纤溶活性的异常。原发性头痛者中存在着缺血性ＣＶＤ的高危个体，临床医师应对其引起重视，及时给予针对性治疗，以防止脑梗塞的发生。

Abstract We detected the changes of activities of tissue type plasminogen activator (t PA) and its rapid inhibitor(PAI 1) in plasma in the patients with migraine and tension type headache(TTH) by chromophore substrate assay. We found that the activities of t PA had no significant changes in plasma in two kinds of idiopathic headache, but the activities of PAI 1 increase significant which implied that there existed the injuries of vascular endothelial cells (VECs) and the abnormalities of fibrinolytic activity in plasma. We think that there present high risk individuals of ischemic cerebral vascular disease among the patients with idiopathic headache. Clinical physician should pay more attention to the patients with migraine or TTH in order to find the prethrombotic individuals and to give the effective treatment, to avoid the occurence of cerebral infarction.