谷胱甘肽硫转移酶基因GSTM_1及GSTT_1缺失与肺癌发病关系的研究

Glutathione S transferase GSTM 1 and GSTT 1 genotypes and susceptibility to lung cancer

在我国肺癌高发区云南省宣威市进行了一次１１配对的以人群为基础的病例对照研究。共收集８６例新发肺癌病人，并选择８６例与病例相同性别、相同燃料品种、年龄相差２岁以内的宣威居民作为对照。采集研究对象的口腔细胞做ＧＳＴＭ１及ＧＳＴＴ１基因型鉴定。结果发现肺癌组的ＧＳＴＭ１缺失率高于对照组，ＯＲ值为２．３９（９５％可信限：１．２５～４．５６）。多因素的条件Ｌｏｇｉｓｔｉｃ回归分析调整吸烟、慢性阻塞性肺部疾患（ＣＯＰＤ）、一生中无烟囱用煤吨数后，ＯＲ值为２．６２（９５％可信限１．３３～５．１５）。但没有发现ＧＳＴＴ１基因的缺失与肺癌的显著联系。

Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing\ 100050,China A 1:1 matched population based case control study was conducted in Xuanwei City, Yunnan Province, where the lung cancer mortality is among China's highest. In this study there were 86 newly diagnosed lung cancer cases and 86 matched control subjects with the same sex, fuel type used, and age(±2 years). Buccal cells were collected from each subject to determine the genotypes of GSTM 1 and GSTT 1. It was found that the rate of GSTM 1 null genotype was higher in the case group than in the control group, and its odds ratio was 2 39(95%CI: 1 25～4 56). The odds ratio became 2 62(95% CI:1 33～5 15) when other possible confounding factors such as smoking, COPD, and the lifetime exposure to unvented fuel combustion (tons) were adjusted. No association was found between GSTT 1 null genotype and lung cancer. The rate of GSTM 1 null genotype in Xuanwei City was found to be similar to those of other Chinese populations.