食管癌放疗前后血清可溶性肿瘤坏死因子受体1的变化和意义

Study on the change tendency of serum levels of soluble tumor necrosis factor receptor 1 beford and after radiotherapy in esophageal carcinoma patients

用双抗体夹心酶联免疫吸附法（ＥＬＩＳＡ）测定了４７例食管癌患者放疗前、后血清可溶性肿瘤坏死因子受体１（ｓＴＮＦＲ－１）水平。结果显示：食管癌患者放疗前血清ｓＴＮＦＲ－１水平显著高于正常对照组（Ｐ＜０００１），且水平和食管病变长度呈正相关。放疗后血清ｓＴＮＦＲ－１完全缓解（ＣＲ）组可恢复到正常水平，而部分缓解（ＰＲ）组高于正常对照组（Ｐ＜０００１）及ＣＲ组（Ｐ＜００１）。放疗后追踪检测血清ｓＴＮＦＲ－１水平，可预示肿瘤有无未控、复发或转移。因此，我们认为血清ｓＴＮＦＲ－１水平测定对判断食管癌患者疗效及预后具有一定的应用价值。

The serum levels of soluble tumor necrosis factor receptor 1(sTNFR-1)before and after radiotherapy in 47 esophageal carcinoma patients were measured by ELISA.The data showed that the serum sTNFR-1 levels in patients were significantly higher than that of healthy controls( P <0 01),and that the serum sTNFR-1 levels correlated with the length of esophagus involved.The serum sTNFR-1 levels was remarkable reduced at the end of radiotherapy( P <0 01)in proportion to the immediate radiotherapeutic response.36 patients were tested during 3 to 6 months after radiotherapy,the serum sTNFR-1 levels elevated in 24 patients with disease uncontrolled or local recurrence or metastasis.It is suggested that measurement of the serum sTNFR-1 in esophageal carcinoma patients is useful for the evaluation of the efficency of treatment and prognosis.