脊索瘤针吸细胞学诊断探讨

The Approach of Fine Needle Aspiratiopn Biopsy of Chordoma

８例脊索瘤（１例骶尾部，２例颈部，５例颅底部）治疗前经针吸细胞学诊断。所有病例都有共同的细胞学表现：有两种细胞成份：一种是有丰富泡沫状或空泡状胞浆的圆形、卵圆形或多边形液滴状细胞，另一种是无胞浆空泡的小圆形、短梭形或星形细胞；多数细胞核圆形或卵圆形无明显异型，核染色质轻度增多、分布均匀，核浆比例不高；细胞单个散在或排列为松散的细胞群；涂片背景中有多少不等的粘液状物。本资料分析表明针吸细胞学结合临床及Ｘ线所见可以诊断脊索瘤。

Chinese Academy of Medical Sciences,Beijing 100021 8 Patients with chordoma (one saeral,two cervical,five clivus tumors) were diagnosed by fine needle aspiration(FNA).All the cases shared the same cytologic features.There were two cell populations in the smears;one was made up of rounded、oval or polygonal cells with abundant bubbly cytoplasm and another were small rounded and spindled or stellated cells without vacuole.Most of these cells had small rounded or oval bland nuclei and low nuclear cytoplasmic ratio.These cells occurred as dispersed single cells or in loose clusters.There was also a varied volume of mucoid matrix.From this study we conclude that a diagnosis of chordoma can be reached by FNA,provided the findings are carefully evaluated in relation to the clinical and roentgenographic findings.