摘要
本文对我院1989~1993年收治30例复发性卵巢上皮癌,其中16例术前、术后腹腔化疗加静脉化疗,14例术后加静脉化疗,2年生存率分别为438%(7/16)、143%(2/14)(P<005)。结果表明以手术为主的综合治疗复发性卵巢上皮癌能提高生存率,腹腔化疗在辅助治疗中起重要作用。767%。术后残余瘤的大小仍是影响预后因素之一,本组术后残瘤≤2cm平均生存20个月,与Moris[3]报道残余瘤≤2cm平均生存163~18个月相似,因此认为二次手术虽然难度大,但应尽量切除复发灶及受侵的脏器,使残瘤直径最大限度≤2cm,提高最佳切除率,以利于增加二线化疗效果。32化疗在辅助治疗中的作用卵巢癌复发的部位多数在盆腹腔内,这样给腹腔化疗带来有利的治疗条件。已证实腹腔化疗可使局部获得药物浓度高于静脉给药的10~1000倍[4]。Piver[5]报道腹腔化疗对难治性,复发性卵巢癌作为拯救性治疗方法。本组结果表明,16例术前、术后腹腔化疗,其中有11例腹水完全控制,1例肝转移缩小,4例陶氏腔结节结缩小,2年生存率为438%(7/16)比术后单纯静脉化疗生存率143%(2/14)要高。认为以手术为主的综合治?
From 1989~1993,30 patients with recurrent epithelial ovarian cancer were treated at our hospital.16 of 30 patients were adminstered by combing intraperitoneal chemotherapy of the pre-postoperation and intravenous infuison,14 patients were treated by postoperation and intravenous infusion.The 2-year survival rate was 43 8%(7/16)、14 3%(2/14)respectively ( P <0 05).Results suggest that surgery based combination therapy may improve the survival rate of recurrent epithelial ovarian cancer.The intraperitoneal chemotherapy play an importance role in the adjuvant therapy.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第1期62-62,71,共2页
Cancer Research on Prevention and Treatment