摘要
为探讨迷走神经刺激（ＶＮＳ）的抗癫痫作用，观察了ＶＮＳ对正常大鼠和戊四氮（ＰＴＺ）致痫大鼠行为和脑电图的影响，结果发现，ＶＮＳ可明显延长致痫大鼠癫痫发作和痫波释放的潜伏期（Ｐ＜０．０５），减轻癫痫发作的严重程度（Ｐ＜０．０１），并能抑制皮层及海马癫痫波的释放（Ｐ＜０．０１），而对正常大鼠脑电图无影响。结果提示ＶＮＳ可明显抑制ＰＴＺ诱导的大鼠癫痫。
To investigate the effect of vagus nerve stimulation (VNS)in epilepsy, the influences of VNS on the behavior and electroencephalography(EEG) of the normal rats and pentylenetetrazol (PTZ) induced seizure rats were observed The results showed that VNS could obviously prolonged the latency of epileptic attacks and epileptic wave discharge ( P <0 05), reduced the intensity of the seizure ( P <0 01), inhibited epileptic wave discharge( P <0 01) Howerer, VNS had no effect on the EEG of the normal rats The results indicated that VNS can significantly inhibit the PTZ induced seizures of rats
出处
《同济医科大学学报》
CSCD
1999年第1期42-44,共3页
Acta Universitatis Medicinae Tongji
关键词
癫痫
戊四氮
迷走神经刺激
脑电图
seizure
\ vagus nerve stimulation
\ electroencephalography
\ pentylenetetrazol
