健康新生儿血清内洋地黄素的测定及其意义

Determination of Serum Endodigin Levels in Healthy Neonates and Its Implication

为了解内洋地黄素在健康新生儿体内的水平，对４５名正常新生儿的８１份血清标本用免疫法（ＡｂｂｏｔＴＤｘⅡ）进行检测。其中８６．２７％的标本＞０．２ｎｇ／ｍｌ，平均浓度为（０．４８±０．２９）ｎｇ／ｍｌ，最高值为１．０８ｎｇ／ｍｌ。经多元回归分析，发现血清内洋地黄素（Ｙ）与日龄（Ａ）及出生体重（Ｂ）呈明显负相关，二者的偏回归系数分别为－０．６３和－０．５１。得出回归方程Ｙ＝１．４６－０．０３Ａ－０．２５Ｂ（Ｒ＝－０．８１）。建议在新生儿期，尤其是第１周，低出生体重的新生儿，在进行地高辛血药浓度监测时，应尽量采用非免疫方法，并对结果作更全面的评价。

To determine the serum endodigin level of healthy neonates, digoxin immunoassay (Abbott Tdx Ⅱ) was used to measure 81 samples of 45 healthy newborns. The serum endodigin levels were over 0 2 ng/ml in the samples of 86 27 % with the mean concentration and maximum being (0 48±0 29) ng/ml and 1 08 ng/ml respectively. Multivariate regression analysis showed that there was a significant negative correlation between age (A) , birthweight (B) and endodigin levels (Y) , with the partial correlation coefficients of them being -0 63 and -0 51 respectively. The regression equation Y =1 46-0 03 A -0 25 B ( R =-0 81) was obtained. It was suggested that non immunoassay methods should be used to determine the serum digoxin levels of neonates, especially for those who were younger than 7 days and had low birthweight and that the results of drug monitoring should be completely evaluated.