摘要
应用微波幅射ＳＰ方法检测１００例胃癌中ＣＤ３４和Ｐ５３表达，结果：Ｐ５３蛋白阳性表达率５２％，Ｐ５３异常表达与胃癌分化程度，浸润深度无关（Ｐ＞０．０５），而与临床分期、淋巴结转移和预后有密切关系（Ｐ＜０．０５）；低分化胃癌组和进展期Ⅱ、Ⅲ、Ⅳ期胃癌微血管密度（ＭＶＤ）明显高于高分化胃癌组和Ⅰ期胃癌（Ｐ＜０．００１），有淋巴结转移胃癌ＭＶＤ明显高于淋巴结未转移胃癌（Ｐ＜０．００１），胃癌ＭＶＤ与Ｐ５３表达无关（Ｐ＞０．０５），提示：胃癌中存在Ｐ５３突变，检测Ｐ５３蛋白异常表达可作为胃癌预后判断指标之一，ＭＶＤ与胃癌组织学特征和转移密切相关，ＭＶＤ可能是一个较为独立的预测胃癌预后的重要指标。
The expressions of P53 protein, CD 34 in 100 gastriccarcinoma cases were detected by streptavidin peroxidaseconjugated method (SP) after microwave processing. The results indicated that: P53 expression was detected in 52% of all tumors. No significant correlation between P53 overexpression and grade of tumor differentiation on depth of invasion was detected (P>0.05). The correlations with TNM staging, lymphnode involvement and survial were of margical significance (P<0.05). MVD was higher in poorly differentiated, in advanced stage and in node postive cases (P<0.001). The data suggests that: the immunohistochemical detection of P53 expression is a predictor of outcame of patients with gastric carcinoma. MVD has positive correlation with clinicopthologic feature and metastalis of lymphnodes. MVD may be accepted as an important independent fact for judging prognosis in grastric carcinoma.
出处
《南通医学院学报》
1999年第1期16-17,共2页
ACTA Academiae Medicinae Nantong
