抑郁症患者血清白介素-6、白介素-2与生活事件及应对方式的相关研究

Study on the Correlation of Serum Levels of IL-6 and IL-2 with Life Event and Copying Style in Depression Patients

目的研究抑郁症患者血清白介素-6、白介素-2水平变化及其与生活事件、应付方式间的关系。方法入组60例未经药物治疗的抑郁症患者,进行生活事件量表(LES)、应付方式问卷和汉密尔顿抑郁量表(HAMD)的临床评定。用酶联免疫吸附方法对60例患者进行血清白介素-6(IL-6)、白介素-2(IL-2)检测,并与60名正常人群进行比较。结果抑郁症组血清白介素-2(IL-2)显著低于对照组。抑郁症患者中求助因子与白介素-6的血清水平成正相关(P<0.05)。生活事件总频度及强度、负性事件频度及强度与血清白介素-6(IL-6)、白介素-2(IL-2)水平无明显相关(t=-2.283,P>0.05)。抑郁患者较健康人群经历更多的负性生活事件,且较多采用不成熟应付方式,其差异有统计学意义(P<0.05)。结论抑郁症患者存在部分细胞因子分泌水平的下降;抑郁患者较健康人群经历更多的生活事件,而多采用不成熟应付方式;血清白介素-6、白介素-2浓度与生活事件及应付方式的相关性有待进一步研究。

Objective To analyze possible correlation of serum levels of IL-6and IL-2 with life event and copying style in depression patients.Methods A total of 60 non-drug therapy depression patients were recruited and assessed by using Life Event Scale （LES）,Copying Style Questionnaire and HAMD.Serum levels of IL-6,IL-2 were evaluated using ELISA method in 60 patients and 60 healthy controls.Results The depression patients had significantly lower serum level of IL-2 than the control group （P〈0.01）.The use of help copying in patients was significantly correlated with serum level of IL-6（P〈0.05）.The other copying styles of depression and the score of life event were no correlated with level of IL-6and IL-2 （t=-0.283,P〈0.05）.Compared with the controls group,the patients experienced more stressful life events and used more negative copying styles （P〈0.05）.Conclusion Depression may have decreased serum levels of cytokines and the patients experience more stressful life events and use more negative copying styles.The levels of IL-6 and IL-2 are not completely correlated with life event and copying styles.