SMAR1和CYCLIND1蛋白在大肠癌中的表达及临床意义

Expression and Clinical Significance of SMAR1 and CYCLIND1 in Colorectal Carcinoma

目的检测SMAR1和CYCLIND1蛋白在大肠癌中的表达及临床意义。方法以大肠癌旁正常组织30例为对照,免疫组化检测128例大肠癌组织SMAR1、CYCLIND1蛋白的表达,分析SMAR1、CYCLIND1表达与临床病理因素的关系及其对大肠癌预后的影响。结果 SMAR1、CYCLIND1蛋白在大肠癌组织和正常组织的阳性表达率分别为44.5%vs76.6%和61.7%vs13.3%,差异均具有统计学意义;SMAR1蛋白的表达与大肠癌Dukes分期、浸润深度、淋巴结转移及分化类型相关(P<0.05);SMAR1蛋白表达与CYCLIND1的表达呈负相关(r=-0.75,P<0.05);SMAR1蛋白低表达、CYCLIND1蛋白高表达的大肠癌患者预后较差。结论 SMAR1、CYCLIND1蛋白的表达与大肠癌的临床病理学特征密切相关,可能参与了大肠癌的侵袭和转移,并对大肠癌的预后产生影响。

Objective To explore the expression of SMAR1 and CYCLIND1 proteins in colorectal carcinoma and their functions in the prognosis of colorectal carcinoma（ CRC ）. Methods We measured SMAR1 and CYCLIND1 expression in 128 specimens of CRC and 30 specimens of normal colorectal tissue by immunohistochemistry,and analyzed the relationship between these protein expression and the clinicopathological parameters,and explored the prognosis in CRC. Results The positive rates of expression of SMAR1 and CYCLIND1 in CRC specimens and normal co]orectal tissue were 44.5% vs 76.6% and 61.7% vs 13.3% ,with a significant difference. The expression of SMAR1 protein was correlated with Dukes stage, infiltration degree, lymphatic metastasis and the degree of cancer differentiation（P〈0.05） ;The expression of SMAR1 protein was negatively correlated with tha! of C YCLINDI protein（r=-0.75 ,P〈0.05 ）. The low expression of SMAR1 and high expression of CYCLIND1 protein in CRC had poor prognosis. Conclusion SMAR1 and CYCLIND1 expression is correlated with the clinical path physiological characteristics in CRC,and the proteins might be correlated with the local invasion,distant metastasis and the prognosis of CRC.