摘要
目的:观察急慢性白血病患者骨髓血管新生情况,分析血管内皮细胞生长因子(VEGF)在急慢性白血病患者中的表达及意义。方法:应用vWF标记免疫组化法观察骨髓微血管密度,ELISA法检测血浆VEGF含量。结果:40例初诊白血病患者骨髓微血管密度(MVD)较对照组明显增高,治疗后获缓解者骨髓MVD较治疗前明显降低,AL组与对照组相比差异无统计学意义,CML组与正常组的差异仍有统计学意义。45例初诊白血病患者血浆VEGF含量明显高于对照组,化疗后获完全缓解的白血病患者血浆VEGF含量较化疗前降低,但与对照组的差异无统计学意义。结论:血管新生与白血病的生成密切相关,抗血管新生可能是治疗白血病的一种有效策略。
Objective：To observe the bone marrow angiogenesis in acute and chronic leukemia, and to evaluate the expression of vascular endothelial growth factor （VEGF） in lenkemiapatients. Methods： Bone marrow （MVD） microvessel density was assayed by vWF immunohistochemical method. The degree of VEGF concentration in plasma was detected by ELISA. Results：The bone marrow MVD in 40 leukemia patients at newly diagnosed was significantly higher than that in the control group. The hone marrow MVD of the remission group was significantly lower than that of newly diagnosed group. And no significant difference was found between the remission group of AL and the control group. The plasma VEGF concentration of newly diagnosed leukemia group was （271.02 ± 67.02 ） pg/ml, which was significantly higher than that of the control group （97.69 ± 5.52） pg/ml （ P 〈 0.01 ）. The plasma VEGF concentration of the complete remission group significantly decreased to normal level. And significant difference was found between the remission group and the control group. Conclusion： Bone marrow angiogenesis plays a key role in the pathogenesis and development of leukemia. Antiangiogenie therapy may be able to constitute a novel strategy for the treatment of 1 eukemia.
出处
《医学信息（中旬刊）》
2010年第7期1746-1747,共2页
Medical Information Operations Sciences Fascicule
