不同化疗途径对中晚期胰腺癌治疗价值的分析

Therapeutic values of different chemotherapy routes in the advanced pancreatic carcinoma

目的评价不同化疗途径对中晚期胰腺癌的治疗价值。方法对15例中晚期胰腺癌患者行单纯静脉化疗,15例行介入动脉化疗,15例行胃十二指肠动脉插管化疗;对患者的临床受益反应、客观疗效、不良反应以及生存期进行分析。结果三组病例的临床受益率分别为25.0%、61.5%和76.5%(P<0.05);有效率分别为33.3%、46.2%和64.7%(P>0.05);出现严重不良反应的病例分别为4例、2例和1例(P>0.05);中位生存时间分别为8.0、9.0和11.5个月(P<0.05)。结论行胃十二指肠动脉插管化疗可提高中晚期胰腺癌患者的临床受益率,疗效较好,并可延长患者生存期。

Objective To evaluate the therapeutic values of different chemotherapy routes in the advanced pancreatic carcinoma.Methods Fifteen cases were given intravenous chemotherapy,15 cases were given interventional arterial chemotherapy,15 cases were given gastroduodenal arterial intubation chemotherapy.The clinical beneficial response,objective response,side effects and survival time of all patients were analyzed.Results The clinical beneficial response rates of three groups were 25.0%,61.5% and 76.5%,respectively（P0.05）;the effective rates were 33.3%,46.2%and 64.7%,respectively（P0.05）.Four,2 and 2 cases showed serious adverse reaction in the three groups,respectively.The median survival time was 8.0,9.0 and 11.5 months,respectively（P0.05）.Conclusion Gastroduodenal arterial intubation chemotherapy can enhance the clinical beneficial response rate and effectively prolong the survival time of patients with advanced pancreatic carcinoma.